Chloroquine and cancer stem cells

Discussion in 'Trusted Online Pharmacy' started by Vlad., 23-Feb-2020.

  1. gosh1 XenForo Moderator

    Chloroquine and cancer stem cells

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    Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Chloroquine should be further explored in the clinical setting as its success may help to more rapidly improve the poor prognosis of patients with pancreatic cancer. ©2014 American Association for Cancer Research. The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Author links open overlay panel Diana H. Liang a b 1 Dong Soon Choi b c 1 Joe E. Ensor b c Benny A. Kaipparettu d Barbara L. Bass a Jenny C. Chang b c. Triple negative breast cancer TNBC is known to contain a high percentage of CD44 +/CD24 −/low cancer stem cells CSCs, corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine CQ, an antimalarial drug, is a lysotropic reagent which inhibits autophagy.

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    Chloroquine and cancer stem cells

    The autophagy inhibitor chloroquine targets cancer stem cells., The autophagy inhibitor chloroquine targets cancer stem.

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  5. The cancer cells in the study ended up being highly sensitized to some of these agents, for example Vitamin C 4-10 x more sensitive, Berberine and Chloroquine. It's noteworthy that, following Docycycline treatment, cells became sensitive to Vitamin C at a dosage level which is reachable orally IC-50 = within the range of 100uM - 250 uM.

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    Because autophagy seems to contribute to promote cancer, chloroquine may sensitize cancer cells through inhibiting autophagy. The dosage of chloroquine usually ranges between 100 and 500 mg/day. Side effects are minimal at low doses, while many more toxic effects occur at higher doses, such as visual disturbances, gastrointestinal upset, electrocardiographic changes, headache, and pruritus. Moreover, organs in which autophagy also plays a homeostatic role, such as the neurons, liver, hematopoietic stem cells, and heart, may be sensitive to the combined use of chloroquine and anticancer drugs. Here, we summarize the functions of autophagy in cancer and kidney injury, especially focusing on the use of chloroquine to treat cancer. Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling. Balic A1, Sørensen MD2, Trabulo SM3, Sainz B Jr1, Cioffi M1, Vieira CR1, Miranda-Lorenzo I1, Hidalgo M4, Kleeff J5, Erkan M5, Heeschen C6.

  6. n1ptun User

    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine and Hydroxychloroquine • LITFL • Toxicology.
  7. stoyan_sto New Member

    When you have Sjogren's syndrome, your eyes, mouth, and other parts of your body get dried out. It's natural to worry when you learn you've got a lifelong disease that will need regular care. Immune & Autoimmune - Lupus Plaquenil - when to take the 2. Plaquenil Uses, Dosage & Side Effects - Sjogren's Syndrome Symptoms, Causes, Diagnosis, Treatment
  8. SergeySa XenForo Moderator

    Plaquenil Oral Uses, Side Effects, Interactions. Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for.

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.
  9. farset77 Well-Known Member

    Allergic reaction to Plaquenil Lupus Forums at The Lupus. If the rash goes it would tend to indicate that it is caused by the Plaquenil. But they might never know. The longer you keep taking it the worse it will get and the longer for it to go.

    Immune & Autoimmune - Lupus Anyone Get An Itchy Rash From