Although I take Enbrel, and MTX, neither one work as well as the Plaquenil and the fatigue and joint pain have returned full force. I had to get off of plaquenil as well b/c of toxicity and benign tumors behind my eyes. I'm just wondering if any of you here have had to stop taking Plaquenil and if so what you replaced it with? Not knowing what your dx is, I don't know what to tell you. I haven't found a replacement except that I started my cytoxan every month now. Plaquenil and tongue swell Blood clots during period with plaquenil Treatment is to stop the medication. “There are plenty of alternatives to hydroxychloroquine,” Dr. Alexander said. “But as with any drug, it should be monitored carefully.” It should push arthritis patients and their doctors to seek out safer available alternatives. Safe, Natural Alternatives to Arthritis Drugs Top Doc Glenn Frey's death, tied in part to rheumatoid arthritis medications he was taking, is a 'wake-up call' about the dangers of powerful drugs used to treat the condition, a top doc says. My family doctor just suggested 3 ALEVE per day as an alternative- she HATES Plaquenil -my rheumatologist prescribes it for everyone she says right off the bat- and it is DANGEROUS I also seem to be having a lot of anxiety and I never had this before I stopped my Plaq Am I just losing my mind? All I can do is offer you my sympathy and suggest you talk to your rheumy or hope that others here have an answer for you. I found that some of my symtoms came back after I got off of plaquenil too but I never found something to really "replace it" unforntunately. Yes I do get some kind of strange migraines but without the pain??? (If anything) Since stopping it even the sun is now my worst enemy and I have had to get a pair of sun glasses.. Hi momto3, Wow, I hate to hear that you had to stop taking plaquenil. Since you're taking Enbrel and MTX, I suppose you have RA and I can't imagine having that and not being able to take plaquenil. I have suffered with migraines for thirty years and the only true relief I've ever gotten are from accupuncture and immitrex. I've had other problems as well but I don't think those would help you b/c they are more related to SLE. Alternatives to hydroxychloroquine for arthritis Hydroxychloroquine Compared to Alternatives -, Safe, Natural Alternatives to Arthritis Drugs Top Doc. Adverse effects of long term use of plaquenil Alternatives to methotrexate MTX are sometimes used for the initial treatment of rheumatoid arthritis RA either because of comorbidities that present an absolute or relative contraindication to MTX, the initial disease-modifying antirheumatic drug DMARD usually employed for treating RA, or because of patient or clinician preferences. Alternatives to methotrexate for the initial treatment of.. Alternatives to plaquenil Anti-Inflammatories discussions.. Hydroxychloroquine Side-effects, uses, time to work. Oct 22, 2007 All three of the TNF inhibitors- Enbrel, Remicade and Humira have been approved for the treatment of psoriatic arthritis. Talk to your rheumatologist. My rheumy has just prescribed Plaquenil for my SS. Reading the warnings, I see that there is concern about effects on the eyes retinas. I am very concerned about this and am wondering if anyone out there has been put on an alternative drug to treat their SS. I have several issues with my. They want me to try cheaper alternatives before they will pay for hydroxychloroquine. I can take it but I would have to pay a high price for it. Their suggestions are OTC options like Aleve or the prescriptions Mefloquine HCL or Chloroquine PH.