Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Benefits of taking plaquenil Dizziness and plaquenil Although prednisone rarely has a direct interaction with other medications, there is an increased risk of infection when combining prednisone with other medications that affect your immune system. Additionally, when taking prednisone with NSAIDs such as naproxen or ibuprofen, there can be an increased risk of stomach ulcers. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. If you take medications such as estrogens or barbiturates with prednisone, drug interactions may potentially occur. These interactions can increase your risk of side effects, affect the level of prednisone in your blood, or decrease the effectiveness of some medications. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Prednisone and hydroxychloroquine interaction Prednisone and Plaquenil question" Lupus Community., Prednisone and Plaquenil DailyStrength P62 chloroquineDoes plaquenil cause hair to.lightenGeneric name of chloroquine Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Hydroxychloroquine Reviews Everyday Health. Prednisone Drug Interactions - eMedTV Health Information.. Plaquenil vs. Prednisone Prescription Treatment for.. Prednisone can potentially interact with certain other medications. Some of these medicines that may lead to prednisone drug interactions include Barbiturates, including Amobarbital Amytal ® Butalbital Fioricet ®, Fiorinal ® Pentobarbital Nembutal ® Phenobarbital Luminal ® Secobarbital Seconal ® Our Prednisone Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Prednisone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you.