To characterize structural changes of HCQ retinopathy with SD-OCT after drug cessation. Setting: Private practice and academic institution. Patient Population: Patients at New England Eye Center and Ophthalmic Consultants of Boston in Boston, MA diagnosed with HCQ retinopathy and followed after drug cessation. Plaquenil 200mg tablets 100 Hydroxychloroquine pulmonary fibrosis Plaquenil joint pain Background/Aims Hydroxychloroquine HCQ retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography OCT abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field HVF testing. Methods Data from. A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. Dec 04, 2014 On SD-OCT, HCQ retinopathy manifests as disruption, or complete loss, of the outer nuclear layer, external limiting membrane, inner/outer segment junction, and RPE in the parafoveal region Fig. 4. 9 Usually, there is a preservation of the subfoveal retinal tissue. Main Outcome Measures: SD-OCT findings suggestive of HCQ retinopathy before parafoveal ellipsoid disruption. Retrospective clinical data review by the Boston Image Reading Center. Plaquenil retinopathy oct Hydroxychloroquine retinopathy Eye, Hydroxychloroquine Plaquenil Toxicity and. Plaquenil and lovenoxDoes plaquenil affect the kidneysChloroquine scheduled drugPlaquenil pregnancy otis Spectral Domain Optical Coherence Tomography SD-OCT shows that there is early thinning of outer retinal layers, typically with loss of the parafoveal photoreceptor inner segment/outer segment IS/OS junction and central foveal sparing. There is preservation of the RPE and external limiting membrane. Hydroxychloroquine-related retinal toxicity Rheumatology.. Hydroxychloroquine retinopathy A review of imaging. Spectral domain optical coherence tomography as an.. Hydroxychloroquine Retinopathy with SD-OCT Changes and Minimal Fundus Changes The images shown here refer to the same case as "Hydroxychloroquine Retinopathy with Minimal Fundus Changes". This 68 year old woman with systemic lupus erythematosus had been on hydroxychloroquine at a dosage of 400 mg/d 6.52 mg/kg/d for eight years. A cookie-cutter approach to dosing Plaquenil hydroxychloroquine, Sanofi-Aventis, an anti-malarial drug that has been used as a treatment for systemic lupus erythematosus and rheumatoid arthritis. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.