I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Chloroquine is a painless suicide Can plaquenil be used for sgroens syndr A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Today on WebMD Medications That Make You Tired Side effects of Plaquenil and prednisone that are similar include nausea, vomiting, or headache. Side effects of Plaquenil that are different from prednisone include stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or hair loss. You and your doctor should decide whether you’ll take this medication or breastfeed. For seniors This drug is processed by your kidneys. Older adults with reduced kidney function may not be. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Should you take plaquenil with steroids Prednisone and Plaquenil question" Lupus Community., Plaquenil vs. Prednisone Prescription Treatment for. Plaquenil 200 mg tablet Do not abruptly stop taking steroids. You should not stop taking steroids abruptly if you have been taking them for more than 4 weeks. Once your body has adjusted to taking steroids, your adrenal glands may shrink and produce less natural cortisone. Treating Lupus with Steroids Johns Hopkins Lupus Center. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Steroids Side-effects, uses, time to work. You must also make sure to taper EXACTLY as directed by your doctor as not doing so can cause serious issues. If you are having joint pain/inflammation and kidney issues then you should take the prednisone now and continue in confirming your diagnosis of Lupus. As for the plaquenil, this is an 'old school' treatment of Lupus. One Plaquenil tablet contains 200 mg of hydroxychloroquine sulfate, which is equivalent to 155 mg base. Take Plaquenil with a meal or a glass of milk. Malaria. Prophylaxis Adults 400 mg 310 mg base once weekly on the same day of each week starting 2 weeks prior to exposure, and continued for 4 weeks after leaving the endemic area. Interactions between your drugs. There were no interactions found in our database between Plaquenil and prednisone - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.