It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Plaquenil derived from Hydroxychloroquine arthritis research uk If you experience any of the following symptoms, call your doctor immediately reading or seeing difficulties words, letters, or parts of objects missing. sensitivity to light. blurred distance vision. seeing light flashes or streaks. difficulty hearing. ringing in ears. muscle weakness. M, took plaquenil for the past 4 years and I remember having nausea for the first month or so, especially at night when laying down. It did get better, though! level 1 Ginny, I had some very minor diarrhea, nausea, cramping for about a week when I started Plaquenil. Everyone is different, but for me, taking the med about 15 min. after eating, rather than before or with a meal, makes things much easier on my stomach, even for just Advil. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Plaquenil nausea Plaquenil Hydroxychloroquine - Side Effects, Dosage., Plaquenil causing nausea lupus - Does hydroxychloroquine cause diarrheaChloroquine and hydroxychloroquinePlaquenil dermatomyositisCan i drink alcohol taking plaquenil Moderate dry mouth, nausea and vomiting Adherence. Always Burden. Not at all hard to take Dosage 400 mg Daily Advice & Tips This med among several others I take causes me to have a dry mouth. Initially, I also experienced nausea, but after 5 years, that is gone I don't recall when that ended. Evaluations from Patients who take Hydroxychloroquine.. Plaquenil = explosive diarrhea -. Upset stomach from plaquenil - Sjogren's World. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia. Common side effects Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. Dizziness Precautions with this side effect Do not drive, use machinery. Cramps. Headache. Dry skin. Loss of appetite. Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness.