I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Is plaquenil administered subcutaneously Malaria proguanil and chloroquine Plaquenil ear pain Can plaquenil cause eye problems I was on plaquenil for about 6 months. I told my rheumy that I really didnt feel like it was helping much, so he took me off it cold turkey last monday. So this past week I have had several very bad days and a few "normal" days. Im just wondering if it is a coincedence or if stopping the plaq could make me feel worse that quickly. Any ideas? You had to stop all your meds, cold turkey. Did you go off plaquenil? Can you go off all those meds that quickly? Were you on pred, if so how many mgs? I didn't go off any meds when I started on methotrexate. I stayed on plaquenil, my NSAID, everything. What kind of lupus doctor is it? A rheumatologist? If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you, do not stop taking hydroxychloroquine without talking to your doctor. Symptoms of rheumatoid arthritis will return if you stop taking hydroxychloroquine. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Stopping plaquenil cold turkey Quitting Methotrexate Cold Turkey - Arthritis Information, Change in meds - abruptly stopping to start a new Lupus Forums at The. Aralen near meHemozoin chloroquine Aug 26, 2016 Plaquenil damps down the reactiveness of the receptors that send out your “fighters”, which in us is overactive. Rather than strangling the life out of your immune system like steroid meds do, it attenuates the function to closer to normal. Stopping Plaquenil - General Discussion - Life With Lupus. Hydroxychloroquine MedlinePlus Drug Information. Quitting methotrexate cold turkey rheumatoid. Jun 19, 2013 It didn't take me long to feel the effects of stopping. I guess I didn't realize how much it was helping me. So far I feel More tired Breathing is more difficult Feels like I am drowning Arms and legs are tingling Numb hands and feet Headache I don't know if this is the result of stopping Plaquenil or just how my Sarcoidosis is presenting. So that's the update. The lesson here is - for those who need to go off plaquenil, be careful about just going off it cold turkey. Obviously some of CAN do that, but if you don't know if you're one of them - better to be on the safe side and wean slowly. Take it from me! I am feeling much better after bumping my dose back up over the last few. Feb 19, 2020 SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.