I am not shocked about having it just being diagnosed with it. I have seen my rheumatologist for five years and I guess she just thought it was time. Hydroxychloroquine bursitis Plaquenil and dry lips I recently went on Plaquenil a few months ago, and I have been noticing how much weight I've been losing. I feel like I am losing too much weight. I am a thin person, and I am sick very often. Last week, I lost three pounds, and the week before I lost two pounds. Everyone keeps commenting that I'm. Hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. These are appropriate only if major organ involvement isn't present. Plaquenil is the newest & safest in the class. The drug helps with skin rashes, hair loss, mouth ulcers, joint pain & swelling, fatigue, etc. It takes perhaps 3-4 months to build up & reach full effect. GOOD NEWS hair loss & weight gain are NOT associated with Plaquenil. She tried to put me on it two years ago even before she diagnosed me because she has always suspected lupus. Anyway, I'm scared to death to take plaquenil but I know that I probably should. Weight loss methotrexate and plaquenil Plaquenil Side Effects Common, Severe, Long Term -, Methotrexate and plaquenil - Plaquenil dose calculatorPlaquenil normal dosagePlaquenil fatigue lupusMoa of chloroquine in malariaPlaquenil and mobic The effects of methotrexate and hydroxychloroquine combination therapy vs. and preventing future functional loss. Body Weight Classified Low-Dose Leflunomide in. Effects of methotrexate and hydroxychloroquine combination.. Want to know good stuff about plaquenil - HealthBoards. Plaquenil vs Methotrexate Antineoplastics Cancer drugs discussions.. Oct 12, 2016 In multivariable models, more weight loss and a greater risk of weight loss odds ratio 1.73 were evident among those receiving leflunomide compared to those receiving methotrexate. Treatment with prednisone was associated with greater weight gain—an average of 0.072 kg/m2. Side effects of Plaquenil that are different from Rheumatrex and Trexall include stomach pain or cramps, loss of appetite, weight loss, diarrhea, spinning sensation, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or hair loss. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.