Why chloroquine is given in loading dose

Discussion in 'Canada Online Pharmacies' started by gghfrrcx, 13-Mar-2020.

  1. plesenya User

    Why chloroquine is given in loading dose


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. What I’m wondering is if there is any relationship with increasing the loading dose and the time taken to reach the steady state. For example, if a greater loading dose was given for a particular drug, would this decrease the time taken to reach the steady state compared to smaller loading dose? Thank you very much in advance. Kind Regards, Sarah Assumption that the loading dose had not been given either. She called pharmacy asking for the loading dose and pharmacy sent up another loading dose, which was administered for the second time. Certain medications require a loading dose, or a larger one-time dose, to reach therapeutic levels with-in the body rapidly. 2,3 Thereafter, the.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    Post-exposure Chloroquine Prophylaxis COVID19, What is a Loading Dose? – Certara

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  4. By the time the government approves any vaccination, the damage by COVID-19 will be done. Why not use something we have available already? Chloroquine. It was cheap and readily available. South Korea included it’s use in their guidelines, and they had an order of magnitude fewer deaths than China! An Effective Treatment for COVID-19

    • Chloroquine for Coronavirus COVID-19 – why aren’t we using..
    • Preventing Errors Associated with Loading Doses of Medications.
    • Loading Drug Dose - an overview ScienceDirect Topics.

    To avoid nausea and vomiting chloroquine should be administered after meals. If part or all of a dose is vomited, the same amount must immediately be readministered. Adults, including pregnant women, and children Total dose 25 mg/kg given over 3 days. Day 1 10 mg/kg, followed by 5 mg/kg 6-8 hours later. Days 2 and 3 5 mg/kg in a single dose. Dosage. Chloroquine can be administered either orally or parenterally for treatment of malaria, but prophylaxis is given in tablet form. An effective blood concentration is reached within 2-3 hours if a loading dose of 600 mg base is used. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart.

     
  5. www32 Guest

    Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. UpToDate Maternal use of hydroxychloroquine is associated with a. Hydroxychloroquine Use in Lupus Patients during Pregnancy.
     
  6. eugenek Guest

    Discoid Lupus Erythematosus Medication - Medscape Reference Aug 21, 2018 Hydroxychloroquine is the drug of choice when a systemic agent is needed for discoid lupus erythematosus DLE. Chloroquine is second-line antimalarial therapy. Chloroquine and hydroxychloroquine should not be used in combination due to the increased risk of ocular toxicity.

    Retinal Physician - Hydroxychloroquine Maculopathy An Update.